The Science

The Science behind Every Scoop

We're obsessed with clinical dosing, ingredient transparency, and formulas that actually work. No proprietary blends. No fairy dust. Every ingredient at the exact dose studied in peer-reviewed research.

Explore Ingredients

Clinically Dosed, No Compromises.

Every Nello formula is built around ingredients at the proven doses shown to work in peer-reviewed clinical studies. No micro-dosing, no proprietary blends hiding behind label tricks.

We publish every ingredient and every dose on the label. Full transparency, always.

Third-Party Tested. Every Batch.

Every batch of every Nello product is independently tested for purity, potency, and banned substances before it ships. We use GMP-certified facilities based in the US for all products.

No shortcuts. No exceptions.

The Best Forms, Not the Cheapest.

We source patented, clinically studied forms of every ingredient: KSM-66 Ashwagandha, SRI-81 Shatavari, GeniusPure Alpha-GPC, Maizinol. These cost more. They work better. That's the point.

Every supplier is vetted. Every certificate of analysis is verified.

"If it doesn't work, why take it? If it doesn't taste good, nobody will. We made emotional wellness transparent, clinically dosed, and actually enjoyable. No mystery blends. No fairy dusting. Just wellness you can feel."

— Connor Noe + Mason Porter, Nello Co-Founders

Quality Assurance

From Raw Material to Your Hands

Every batch goes through a rigorous multi-step testing pipeline before it ships. No exceptions.

1

Raw Material Verification

Every incoming ingredient is tested for identity, purity, and potency before it enters our facility. The Certificate of Analysis verified against independent lab results.

2

GMP Manufacturing

Formulated and manufactured in GMP-compliant facilities. Strict environmental controls, batch tracking, and real-time quality monitoring.

3

Third-Party Testing

Every finished batch is sent to an independent ISO-accredited lab.

4

Release & Ship

Only batches that pass all testing stages are released. No batch ships without sign-off.

🏭GMP Certified
🔍Third-Party Tested
🇺🇸Made in the USA
📋Full Label Transparency
🚫No Proprietary Blends

The Research

Backed by Real Science

KSM-66 Ashwagandha

A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults

-27.9%

Serum cortisol reduction vs. placebo

A 60-day randomized, double-blind, placebo-controlled trial showed KSM-66 at 600mg/day significantly reduced serum cortisol levels and perceived stress scores in adults with chronic stress.

Indian Journal of Psychological Medicine, 2012 View Study →

Magnesium Glycinate

Effects of Magnesium Supplementation on Subjective Anxiety

Significant

Reduction in anxiety markers across 18 studies

A systematic review of 18 studies found that magnesium supplementation reduces subjective anxiety and stress markers, with highly bioavailable forms (like glycinate) showing the strongest effects.

Nutrients, 2017 View Study →

Lion's Mane

Improving effects of the mushroom Yamabushitake (Hericium erinaceus or Lion's Mane) on mild cognitive impairment: a double-blind placebo-controlled clinical trial

+14.9%

Improvement on cognitive function scale

A 16-week double-blind trial found that adults taking 1000mg Lion's Mane daily showed significant improvements in cognitive function compared to placebo, with effects maintained throughout supplementation.

Phytotherapy Research, 2009 View Study →

L-Theanine

The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review

Significant

Assistance in reduction of stress and anxiety in people exposed to stressful conditions

Our findings suggest that supplementation of 200-400 mg/day of L-THE may assist in the reduction of stress and anxiety in people exposed to stressful conditions.

Plant Foods Hum Nutr., 2020 View Study →

Shatavari

Efficacy and safety of Shatavari root extract in women with Polycystic Ovarian Syndrome: a randomized, double-blind, placebo-controlled trial

PSS score: -6.64 ± 3.99; p < 0.0001

Reduction in psychological stress

Shatavari root extract oral administration can be a safe and effective potential intervention for women with PCOS.

Front Endocrinol (Lausanne), 2026 View Study →

Maizinol

UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State

Up to 30 minutes

Increase in deep sleep time

Collectively, UP165 is a safe nutritional supplement clinically proven for a 24-hour support with better quality and efficiency of sleep at night and an improved mood state and overall well-being during the day.

J Med Food, 2023 View Study →

Our Standard

What We Never Do

No Proprietary Blends

Every ingredient and every dose is printed on the label. We never hide behind a blend name to obscure what you're actually getting.

No Under-Dosing

If a study used 600mg, we use 600mg. We never cut doses to reduce costs. Clinical efficacy requires clinical doses.

No Fillers or Fairy Dust

No microcrystalline cellulose, no magnesium stearate filler, no inactive bulking agents. Every ingredient serves a purpose.

No Unsubstantiated Claims

We only claim what the research supports. No miracle cures, no exaggerated marketing. Just transparent science.

This is the standard. Every product. Every batch. Every time.

The best ingredients, researched for decades.

Every ingredient rigorously tested and clinically validated for efficacy and purity.